Gut microbiota maturation during early human life induces enterocyte proliferation via microbial metabolites
نویسندگان
چکیده
منابع مشابه
Patterns of Early-Life Gut Microbial Colonization during Human Immune Development: An Ecological Perspective
Alterations in gut microbial colonization during early life have been reported in infants that later developed asthma, allergies, type 1 diabetes, as well as in inflammatory bowel disease patients, previous to disease flares. Mechanistic studies in animal models have established that microbial alterations influence disease pathogenesis via changes in immune system maturation. Strong evidence po...
متن کاملThe early life gut microbiota and atopic disease
Background Asthma is the most prevalent of all childhood diseases and accounts for the majority of hospitalizations and school absences in children [1]. Current mouse model research has identified the early life gut microbiota as a potential therapeutic target for the prevention of asthma and atopic diseases [2-4]. We hypothesize that the early life gut microbiota could play a similar preventat...
متن کاملDiversity of the gut microbiota and eczema in early life
BACKGROUND A modest number of prospective studies of the composition of the intestinal microbiota and eczema in early life have yielded conflicting results. OBJECTIVE To examine the relationship between the bacterial diversity of the gut and the development of eczema in early life by methods other than stool culture. METHODS Fecal samples were collected from 21 infants at 1 and 4 months of ...
متن کاملEarly Life Microbiota, Neonatal Immune Maturation and Hematopoiesis
Emerging epidemiologic data supports the hypothesis that early life colonization is a key player in development of a balanced immune system. Events in early life, as birth mode and infant diet, are shown to influence development of immune related diseases, like asthma, diabetes and inflammatory bowl disease, later in life. The intestinal epithelium makes up a physical and biochemical barrier be...
متن کاملThe Effect of Intestinal Microbiota Metabolites on HT29 Cell line by Using MTT Method in Patients with Colorectal Cancer
Background: Colorectal cancer is one of the most common malignant tumors, Human guts harbor abundant microbes that adjust many aspects of host physiology. Increasing studies show that gut microbiota plays a significant role in the incidence and expansion of CRC, as a result of virulence factors, bacterial metabolites, or inflammatory pathways. Materials and Methods: In this study, viability o...
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ژورنال
عنوان ژورنال: BMC Microbiology
سال: 2020
ISSN: 1471-2180
DOI: 10.1186/s12866-020-01892-7